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STEP 1: SELECT YOUR DISCOUNT PACKAGE

Congratulations on taking the first step; now comes the most important stage, in which you will choose the protocol that is most important for your current situation.

Average Customer Rating 4.9

4.9/5 (1612 Reviews)

NatureOne Total Renew - Advanced Protocol

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This product sold out 12 times last year. We encourage you to take advantage of the limited sale and buy now. Subscribing protects you against future stock outs.

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As Seen On:

For three years, I used a walker just to get from the bedroom to the kitchen. Six weeks into Total Renew, I realized the walker was still against the wall — and I'd completely forgotten about it. On my daughter's wedding day, I took her arm and walked her down that aisle without thinking about my knees once.

Robert M., 67

Verified Buyer

For seven years, my husband Hank knelt in front of me every morning to put on my shoes. He never complained. But every time, something inside me broke a little. In week five of Total Renew, I bent down and did it myself — no pain, no help. It wasn't about the shoes. It was about my dignity.

Gloria T., 62

Verified Buyer

When arthritis took my fingers, I couldn't hold a screwdriver or button my own shirt. After seven weeks of applying Total Renew, I sat at my workbench and repaired two watches in the same week. My hands are back. And honestly, so am I.

Arthur B., 73

Verified Buyer

I used to make excuses every time Sophie asked me to play outside. I had a knee replacement scheduled and I was terrified. Six weeks into Total Renew, I canceled the surgery. Eight weeks in, I pushed her on those swings until my arms got tired — not my knees.

Linda W., 68

Verified Buyer

Clinically Dosed Ingredients

Backed by 100+ Scientific Studies on Joint and Nerve Pain

Clinically studied therapeutic doses

100% natural, non-GMO & gluten-free

Third-party tested for purity and potency

Stops the Destruction Before It Goes Any Further

Most treatments mute the alarm while the real problem keeps going. Total Renew targets the microscopic enzymes destroying your cartilage at the source — and silences the signal that tells them to attack. The cycle of destruction that's been running inside your joints for years finally stops. Not temporarily. At the root.

Restores Natural Joint Lubrication

Chronic inflammation depletes the synovial fluid that keeps your joints moving smoothly. Without it, every step feels like bone grinding on bone. Total Renew replenishes the key components of that fluid directly at the joint, so the grinding and stiffness gradually give way to the smooth, fluid movement your joints were built for.

Rebuilds What Was Lost — From the Outside In

Once the destruction slows, your body needs the right tools to repair the damage. Total Renew delivers clinically studied compounds directly through the skin to the joint tissue — no detour through the stomach, no absorption loss. Straight to where the reconstruction needs to happen.

Protection That Lasts Beyond the Bottle

The six-month protocol gives your body time to complete a full repair cycle — stop the destruction, rebuild the tissue, fortify the joint. The cartilage you build is real, functional tissue. It doesn't disappear when you stop. A simple maintenance routine afterward is all it takes to keep it that way.

Pure and natural ingredients:

Melittin (Bee Venom Extract)

The cornerstone of the formula. Research from Washington University in St. Louis showed that Melittin, applied topically, penetrates through the skin directly to joint tissue — where it cuts off the inflammatory signal that triggers cartilage-destroying enzymes (MMPs). When the signal stops, the destruction stops.

 Hyaluronic Acid

Standard Hyaluronic Acid can't pass through the skin. The low-molecular-weight version can — reaching the synovial space inside the joint and replenishing the natural lubricant that years of inflammation have stripped away. Less grinding. More glide.

Undenatured Type II Collagen

Formulated at a molecular weight specifically designed to be absorbed through the skin. Clinical trials at Harvard Medical School showed this form of collagen signals the body to stop attacking its own cartilage and start regenerating new tissue. Once the destruction is stopped, this ingredient puts the construction crew to work.

Boswellia Serrata

Validated by research in the Indian Journal of Pharmaceutical Sciences, Boswellia blocks the same inflammatory pathways as cortisone injections — without the side effects and without wearing off. It works alongside Melittin to keep the joint environment stable and prevent the destructive enzymes from returning.

Apigenin (from Chamomile)

A flavonoid found inside chamomile that directly reduces the production of MMP-3 and MMP-13 — the enzymes destroying your cartilage. While Melittin cuts the attack signal, Apigenin reduces how many of those enzymes your body manufactures. A clinical trial from the University of Medical Sciences in Shiraz confirmed meaningful pain reduction and improved mobility with topical chamomile application on arthritic knees.

90-DAY MONEY-BACK GUARANTEE

Give it three full months. Apply it, feel the difference, and decide for yourself. If you don't experience a meaningful improvement in pain, stiffness, and mobility — for any reason — contact our team and we'll refund every dollar. No questions. No hoops. You don't even need to return the jars. The risk is entirely ours.

How is Total Renew different from other joint creams I've tried before?

Most creams stay in the outer layers of skin — they create temporary warmth or numbing but never reach the joint. Total Renew uses low-molecular-weight compounds clinically shown to penetrate through the skin and act directly on joint tissue. The difference isn't just the ingredients. It's where they actually go.

I'm 75 years old. Is my condition too advanced for this to work?

Age alone isn't the deciding factor. Your body doesn't lose the ability to repair cartilage — it loses the tools. Some users in their mid-seventies took a week or two longer to feel the first changes, but once the rebuilding process began, it followed the same pattern as younger users.

Can I take GlucoDrain with other supplements or medications?

Total Renew acts locally at the joint — it doesn't enter the bloodstream the way an oral medication does and doesn't compete with your prescriptions. If you take blood thinners or have a serious underlying condition, check with your doctor first. Not because there's a known risk, but because that's the responsible approach.

How much should I order?

Approximately 30 days with twice-daily use on a single joint area. If you're applying to multiple joints — both knees, a hip, or your hands — consumption will be slightly higher. That's why the six-jar protocol is recommended: you won't run out mid-protocol when consistency matters most.

How soon will I start to feel results?

Most users notice the first changes within two to three weeks — less morning stiffness, slightly easier movement. Between weeks four and six, meaningful improvements in mobility and pain reduction become more apparent. Results build over time; the longer the protocol, the deeper the repair.

How long does shipping take?

Delivery times vary depending on your location. For the United States, delivery typically takes 5 to 7 business days. For other countries, it can range from 7 to 15 business days depending on the region. As soon as your order is dispatched from NatureOne Lab's facilities in Switzerland, you'll receive a tracking code via email and SMS to follow your delivery in real-time right to your door.

Can I use Total Renew on multiple joints at the same time?

Yes. You can apply it to any joint affected by pain — knees, hips, shoulders, hands, ankles. Just account for higher product use per jar if treating multiple areas, and plan your supply accordingly.

Is there anyone who should NOT use Total Renew?

Anyone with a known allergy to bee venom or bee products should not use Total Renew, as it contains Melittin derived from bee venom. If you have sensitive skin or a history of skin allergies, a small patch test on the inside of your wrist before full application is recommended.

What if it doesn't work for me?

You pay nothing. Contact our team within 90 days of your purchase and we'll refund your full order — no explanation needed, no jars to return. We carry the risk completely. Your only job is to give it a real try.